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Q How accurate is magnetic resonance imaging (MRI) for diagnosing multiple sclerosis (MS)?
Clinical impact ratings IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Neurology ★★★★★☆☆
12 electronic databases (to September or November 2004), reference lists, and the National Institute for Health and Clinical Excellence MS guidelines.
Study selection and assessment:
published and unpublished studies in any language that evaluated the accuracy of MRI for early diagnosis of MS in patients presenting with suspected disease. 18 prospective cohort studies (n = 2102) and 11 studies of other designs (mainly case control, n = 2527) met the selection criteria. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS) criteria were used to assess quality of individual studies.
sensitivity, specificity, positive and negative likelihood ratios (LRs), and diagnostic odds ratio (OR) (the odds of positivity in people with MS, divided by the odds of positivity in …
For correspondence: Dr P Whiting, MRC Health Services Research Collaboration, Bristol, UK.
Source of funding: no external funding.
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