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  1. Paul Glasziou, MBBS, PhD
  1. University of Oxford
 Oxford, UK

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    Most of the articles we pick for EBM stand the test of time, and conclusions are rarely changed by subsequent research. However, John Ioannidis has published a fascinating study of this issue by looking at 49 highly cited articles (>1000 citations) from 1990–2003 (

    ) . Of these, 7 were contradicted by subsequent research, but 5 of these were non-randomised studies (including vitamin E and hormone therapy), and 2 were surrogate endpoints. And none of these was selected for the EBM journal. Having said that, this issue does contain a minor update. We had previously published a trial showing no benefit of antibiotics in conjunctivitis, but the meta-analysis in this issue shows a small benefit.

    For those keen on teaching evidence-based medicine, one of the premier events on the international calendar is the biennial meeting in Sicily. So you might like to mark in your diaries that the 4th International Conference of Evidence-Based Health Care Teachers & Developers will be in Sicily, 31 October to 4 November, 2007. You will find more details at

    For folk from developing countries interested in learning about teaching EBM, we have 6 bursaries each year to attend the annual 5 day residential Teaching & Learning EBM course in Oxford. Details and contacts can be found at the Centre for Evidence-Based Medicine website (

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