Statistics from Altmetric.com
Q When used as first line treatment of hypertension, does the efficacy of β blockers for preventing major cardiovascular events differ between younger and older patients?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★★ Cardiology ★★★★★★☆
PubMed (1950 to January 2006), reference lists of hypertension meta-analyses, and experts.
Study selection and assessment
randomised controlled trials (RCTs) with blinded assessment of outcome that compared β blockers with placebo or other antihypertensive drugs as first line therapy for hypertension. 21 RCTs met the selection criteria: 10 trials (n = 50 612) involved younger patients (mean age 46–56 y), and 11 trials (n = 95 199) involved older patients (mean age 60–76 y).
a composite end point of stroke, myocardial infarction (MI), or death; stroke; MI; death; and heart failure.
In younger patients, β blockers …
For correspondence: Dr F McAlister, University of Alberta Hospital, Edmonton, Alberta, Canada.
Source of funding: no external funding.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.