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Q In patients with grass pollen-induced allergic rhinoconjunctivitis, how effective is sublingual immunotherapy with a grass allergen tablet?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Allergy & immunology ★★★★★★☆
METHODS
Design:
randomised placebo controlled trial.
Allocation:
unclear allocation concealment.*
Blinding:
blinded (patients, healthcare providers, and outcome assessors).*
Follow up period:
up to the end of grass pollen season.
Setting:
55 centres in Canada, UK, Germany, Belgium, Austria, Denmark, Sweden, and Norway.
Patients:
855 patients 18–65 years of age (mean age 35 y, 62% men) who had allergic rhinoconjunctivitis during grass pollen season for ⩾2 years and positive result on skin prick test to timothy grass (Phleum pratense). Exclusion criteria included history of asthma, anaphylaxis, or angio-oedema; forced expiratory volume1 <70% predicted; non-grass induced allergic rhinitis; recurrent acute or chronic sinusitis; conjunctivitis, rhinitis, or asthma at randomisation; hypersensitivity to trial medication; and immunotherapy for allergens in the past 5–10 years.
Intervention:
oral P pratense …
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