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Q In preschool children at high risk of asthma, does 2 year inhaled corticosteroid (IC) therapy prevent asthma after treatment is discontinued?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Allergy & immunology ★★★★★★☆ Respirology ★★★★★★☆ Paediatrics ★★★★★★☆
METHODS
Design:
randomised controlled trial.
Allocation:
{concealed*}†.
Blinding:
blinded (patients, healthcare providers, {data collectors, and outcome assessors}†).*
Follow up period:
up to 3 years.
Setting:
5 clinical centres in the US.
Patients:
285 children 2–3 years of age (mean age 3 y, 62% boys) who had wheezing or allergy without other clinically significant medical disorders, were at high risk of the persistence of asthma-like symptoms during their school year, had received ICs for ⩽4 months, and did not require ICs during a run in month.
Intervention:
an IC (fluticasone propionate, GlaxoSmithKline), 88 µg twice daily (n = 143), …
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