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  • 2 year inhaled corticosteroid therapy did not prevent asthma in high risk preschool children after treatment was discontinued

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Therapeutics
2 year inhaled corticosteroid therapy did not prevent asthma in high risk preschool children after treatment was discontinued

http://dx.doi.org/10.1136/ebm.11.6.174

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    Guilbert TW, Morgan WJ, Zeiger RS, et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 2006;354:1985–97.
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 Q In preschool children at high risk of asthma, does 2 year inhaled corticosteroid (IC) therapy prevent asthma after treatment is discontinued?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Allergy & immunology ★★★★★★☆ Respirology ★★★★★★☆ Paediatrics ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    {concealed*}†.

    Embedded ImageBlinding:

    blinded (patients, healthcare providers, {data collectors, and outcome assessors}†).*

    Embedded ImageFollow up period:

    up to 3 years.

    Embedded ImageSetting:

    5 clinical centres in the US.

    Embedded ImagePatients:

    285 children 2–3 years of age (mean age 3 y, 62% boys) who had wheezing or allergy without other clinically significant medical disorders, were at high risk of the persistence of asthma-like symptoms during their school year, had received ICs for ⩽4 months, and did not require ICs during a run in month.

    Embedded ImageIntervention:

    an IC (fluticasone propionate, GlaxoSmithKline), 88 µg twice daily (n = 143), …

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    Footnotes

    • ↵* See glossary.

    • ↵† Information provided by author.

    • For correspondence: Dr T W Guilbert, University of Arizona, Tucson, AZ, USA. guilbert{at}arc.arizona.edu

    • Sources of funding: National Heart, Lung, and Blood Institute; National Institutes of Health; National Jewish Medical and Research Centre.

    Linked Articles

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2006; 11 191-191 Published Online First: 30 Nov 2006. doi: 10.1136/ebm.11.6.191-a