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2 year inhaled corticosteroid therapy did not prevent asthma in high risk preschool children after treatment was discontinued

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 Q In preschool children at high risk of asthma, does 2 year inhaled corticosteroid (IC) therapy prevent asthma after treatment is discontinued?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Allergy & immunology ★★★★★★☆ Respirology ★★★★★★☆ Paediatrics ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, healthcare providers, {data collectors, and outcome assessors}).*

Embedded ImageFollow up period:

up to 3 years.

Embedded ImageSetting:

5 clinical centres in the US.

Embedded ImagePatients:

285 children 2–3 years of age (mean age 3 y, 62% boys) who had wheezing or allergy without other clinically significant medical disorders, were at high risk of the persistence of asthma-like symptoms during their school year, had received ICs for ⩽4 months, and did not require ICs during a run in month.

Embedded ImageIntervention:

an IC (fluticasone propionate, GlaxoSmithKline), 88 µg twice daily (n = 143), …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr T W Guilbert, University of Arizona, Tucson, AZ, USA. guilbert{at}

  • Sources of funding: National Heart, Lung, and Blood Institute; National Institutes of Health; National Jewish Medical and Research Centre.

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