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Q In patients with type 2 diabetes mellitus poorly controlled with sulphonylurea monotherapy, is adjunctive inhaled human insulin (INH) better than adjunctive metformin?
Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★☆☆ Endocrine ★★★★★★
METHODS
Design:
randomised controlled trial.
Allocation:
concealed.*
Blinding:
unblinded.*
Follow up period:
24 weeks.
Setting:
13 centres in Europe, South Africa, Israel, and Brazil.
Patients:
427 patients 35–80 years of age (mean age 60 y, 53% men) who had type 2 diabetes mellitus ⩾6 months, were poorly controlled on sulphonylurea therapy ⩾2 months, and had normal pulmonary function test results. Exclusion criteria included asthma or chronic obstructive pulmonary disease; smoking in the previous 6 months; concomitant therapy with hypoglycaemic agents or agents that may affect glycaemic control; fasting C …
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