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Q In postmenopausal women, does raloxifene reduce the risks of coronary events and invasive breast cancer?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆ Geriatrics ★★★★★★☆ Haematology ★★★★★★☆ Oncology ★★★★★★☆ Rheumatology ★★★★★★☆ Gynaecology ★★★★★★☆ Endocrine ★★★★★☆☆
randomised placebo controlled trial (Raloxifene Use for The Heart [RUTH] trial).
blinded (clinicians, participants, outcome assessors, laboratory staff, and sponsor).*
Follow up period:
median 5.6 years.
177 centres in 26 countries worldwide.
10 101 postmenopausal women ⩾55 years of age (mean 68 y) with or at increased risk of coronary heart disease. Exclusion criteria included recent myocardial infarction (MI) or revascularisation procedure; history of cancer, venous thromboembolism (VTE), heart failure, or chronic liver or renal disease; life expectancy <5 …