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Q Are single dose azithromycin and single dose ciprofloxacin equivalent for treatment of severe cholera in adults?
Clinical impact ratings Tropical & travel medicine ★★★★★★★ Infectious disease ★★★★★★☆ Endocrine ★★★★★★☆
METHODS
Design:
randomised controlled trial.
Allocation:
{concealed*}†.
Blinding:
blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, and monitoring committee}†.*
Follow up period:
48 hours (for primary outcome).
Setting:
a diarrhoea treatment centre in Dhaka, Bangladesh.
Patients:
198 men 18–60 years of age (median age 25 y) who had watery diarrhoea for ⩽24 hours, severe dehydration, a high purging rate (stool volume ⩾20 ml/kg body weight over a 4 hour period after initial rehydration), and isolation of Vibrio cholerae O1 or O139 from a stool or rectal swab sample. Exclusion criteria were concomitant illness or receipt of an antimicrobial agent effective for treatment of cholera.
Intervention:
azithromycin, two 500 mg tablets, plus a placebo formulation of ciprofloxacin …
Footnotes
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↵† Information provided by author.
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For correspondence: Dr D Saha, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. dsaha{at}icddrb.org
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Sources of funding: Pfizer, National Institute of Allergy and Infectious Diseases; Wellcome Trust. Pfizer provided azithromycin tablets, and Square Pharmaceuticals provided ciprofloxacin tablets.
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