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Therapeutics
Dental restoration with amalgam was not worse than resin composite material for children’s health

https://doi.org/10.1136/ebm.11.6.183

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    Bellinger DC, Trachtenberg F, Barregard L, et al. Neuropsychological and renal effects of dental amalgam in children: a randomized clinical trial. JAMA 2006;295:1775–83.
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 Q In children with caries, does dental restoration with amalgam adversely affect neuropsychological and renal functions?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    concealed.*

    Embedded ImageBlinding:

    blinded (data collectors and data analysts).*

    Embedded ImageFollow up period:

    5 years.

    Embedded ImageSetting:

    5 community health dental clinics in New England in the US.

    Embedded ImagePatients:

    534 children 6–10 years of age (mean age 7.9 y, 54% girls) who had ⩾2 posterior teeth with dental caries; had no previous amalgam restoration; and were not previously diagnosed with psychological, behavioural, neurological, immunosuppressive, or renal disease.

    Embedded ImageIntervention:

    amalgam (n = 267) or resin composite material (n = 267). Resin composite material was used to restore caries in the front teeth for all children. Stainless steel crowns were used to restore primary …

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    Footnotes

    • ↵* See glossary.

    • For correspondence: Dr S M McKinlay, New England Research Institute Inc, Watertown, MA, USA. smckinlay{at}neriscience.com

    • Sources of funding: New England Research Institutes and National Institute of Dental and Craniofacial Research.

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2006; 11 191-191 Published Online First: 30 Nov 2006. doi: 10.1136/ebm.11.6.191-a