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Dental restoration with amalgam was not worse than resin composite material for children’s health

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 Q In children with caries, does dental restoration with amalgam adversely affect neuropsychological and renal functions?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (data collectors and data analysts).*

Embedded ImageFollow up period:

5 years.

Embedded ImageSetting:

5 community health dental clinics in New England in the US.

Embedded ImagePatients:

534 children 6–10 years of age (mean age 7.9 y, 54% girls) who had ⩾2 posterior teeth with dental caries; had no previous amalgam restoration; and were not previously diagnosed with psychological, behavioural, neurological, immunosuppressive, or renal disease.

Embedded ImageIntervention:

amalgam (n = 267) or resin composite material (n = 267). Resin composite material was used to restore caries in the front teeth for all children. Stainless steel crowns were used to restore primary …

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  • * See glossary.

  • For correspondence: Dr S M McKinlay, New England Research Institute Inc, Watertown, MA, USA. smckinlay{at}

  • Sources of funding: New England Research Institutes and National Institute of Dental and Craniofacial Research.

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