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Q In pregnant women with prelabour rupture of membranes (PROM) at term, is planned early birth better for the mother and infant than expectant management?
Clinical impact ratings Obstetrics ★★★★★★★ Paediatrics ★★★★★☆☆ Infectious disease ★★★★☆☆☆
Medline, EMBASE/Excerpta Medica, Cochrane Pregnancy and Childbirth Group Trials Register (November 2004), Cochrane Central Register of Controlled Trials (issue 4, 2004), and reference lists.
Study selection and assessment:
randomised and quasi-randomised controlled trials (RCTs) that compared planned early birth (intervention implemented within 24 h) and expectant management (no intervention for ⩾24 h) in pregnant women with PROM at ⩾37 weeks’ gestation. 12 RCTs (n = 6846 women) reporting 13 comparisons met the selection criteria. The active management intervention used was induction of labour with oxytocin in 7 RCTs, prostaglandin in 5 RCTs, and caulophyllum in 1 …
For correspondence: MsP Middleton, University of Adelaide, Adelaide, South Australia, Australia.
Source of funding: National Health Service Programme for Research & Development.