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Q In elderly people with mild vitamin B-12 deficiency and no to moderate cognitive impairment, does daily oral vitamin B-12 with or without folic acid for 24 weeks improve cognitive function?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★☆☆☆ Neurology ★★★★★☆☆ Geriatrics ★★★★☆☆☆
METHODS
Design:
randomised placebo controlled trial.
Allocation:
{concealed*}†.
Blinding:
blinded (participants, clinicians, {data collectors, and data analysts}†).*
Follow up period:
24 weeks.
Setting:
30 service flats and 24 care-facility homes in the Netherlands.
Patients:
195 elderly people ⩾70 years of age (mean age 82 y, 76% women) who lived in the community or in care-facility homes. Exclusion criteria were history of cobalamin deficiency, receipt of cobalamin or folic acid supplements, surgery or diseases of the stomach or small …
Footnotes
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↵† Information provided by author.
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For correspondence: Dr L C de Groot, Wageningen University, Wageningen, The Netherlands. lisette.degroot{at}wur.nl
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Sources of funding: ZON-MV; Kellogg’s Benelux; Foundation to Promote Research Into Functional Vitamin B12 Deficiency and the European Union BIOMED Demonstration Project; Nutricia Health Foundation.
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