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Daily oral vitamin B-12 with or without folic acid for 24 weeks did not improve cognitive function in elderly people

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 Q In elderly people with mild vitamin B-12 deficiency and no to moderate cognitive impairment, does daily oral vitamin B-12 with or without folic acid for 24 weeks improve cognitive function?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★☆☆☆ Neurology ★★★★★☆☆ Geriatrics ★★★★☆☆☆


Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (participants, clinicians, {data collectors, and data analysts}).*

Embedded ImageFollow up period:

24 weeks.

Embedded ImageSetting:

30 service flats and 24 care-facility homes in the Netherlands.

Embedded ImagePatients:

195 elderly people ⩾70 years of age (mean age 82 y, 76% women) who lived in the community or in care-facility homes. Exclusion criteria were history of cobalamin deficiency, receipt of cobalamin or folic acid supplements, surgery or diseases of the stomach or small …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr L C de Groot, Wageningen University, Wageningen, The Netherlands. lisette.degroot{at}

  • Sources of funding: ZON-MV; Kellogg’s Benelux; Foundation to Promote Research Into Functional Vitamin B12 Deficiency and the European Union BIOMED Demonstration Project; Nutricia Health Foundation.

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