Article Text

Download PDFPDF
Environmental and dietary interventions in the first 5 years of life did not reduce risk of asthma and allergic disease

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 Q Does reduction in exposure to house dust mite (HDM) allergens and modification of dietary fatty acids in the first 5 years of life reduce the risk of asthma at 5 years of age?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Allergy & immunology ★★★★★★☆ Paediatrics ★★★★★☆☆


Embedded ImageDesign:

randomised, 2×2 factorial design, placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {participants [diet intervention only], outcome assessors, and laboratory staff}.*

Embedded ImageFollow up period:

5 years.

Embedded ImageSetting:

{antenatal clinics of 6 hospitals in Sydney, Australia.}

Embedded ImageParticipants:

616 pregnant women (mean age 29 y), whose unborn singleton child was at increased risk of developing asthma because of asthma or frequent wheezing in a first degree relative. Exclusion criteria included a cat in the home and a vegetarian diet. Infants born at <36 weeks’ gestation, with birth weight <2.5 kg or significant congenital malformation or neonatal disease were withdrawn. …

View Full Text


  • * See glossary.

  • For correspondence: Dr G B Marks, Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia. g.marks{at}

  • Sources of funding: National Health and Medical Research Council of Australia and New South Wales Department of Health.

Linked Articles

  • Glossary
    BMJ Publishing Group Ltd
  • Other articles noted
    BMJ Publishing Group Ltd