METHODS

Design:

randomised, 2×2 factorial design, placebo controlled trial.

Allocation:

{concealed*}†.

Blinding:

blinded {participants [diet intervention only], outcome assessors, and laboratory staff}†.*

Follow up period:

5 years.

Setting:

{antenatal clinics of 6 hospitals in Sydney, Australia.}†

Participants:

616 pregnant women (mean age 29 y), whose unborn singleton child was at increased risk of developing asthma because of asthma or frequent wheezing in a first degree relative. Exclusion criteria included a cat in the home and a vegetarian diet. Infants born at <36 weeks’ gestation, with birth weight <2.5 kg or significant congenital malformation or neonatal disease were withdrawn. …