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A lifestyle intervention continued to prevent type 2 diabetes in high risk patients after the programme was stopped

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 Q In overweight patients with impaired glucose tolerance, are the benefits of a lifestyle intervention for preventing type 2 diabetes maintained after the programme is stopped?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Endocrine ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

unclear allocation concealment.*

Embedded ImageBlinding:

blinded {study nurse and laboratory staff}.*

Embedded ImageFollow up period:

Median 7 years (median 3 y postintervention).

Embedded ImageSetting:

5 centres in Finland.

Embedded ImagePatients:

522 patients {40–65 years of age} (mean age 55 y, 67% women) with {body mass index ⩾25 kg/m2} (mean 31 kg/m2) and impaired glucose tolerance {(plasma glucose level 140–200 mg/dl [7.8–11.0 mmol/l] 2 h after a 75 g oral glucose tolerance test and fasting plasma glucose level <140 mg/dl [7.8 mmol/l])}† on 2 occasions. Exclusion criteria included {previous diagnosis of diabetes and life expectancy <6 y}†.

Embedded ImageIntervention:

lifestyle intervention, involving a median 20 individual dietary counselling sessions with a nutritionist and advice …

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  • * See glossary.

  • .

  • For correspondence: Dr J Lindström, National Public Health Institute, Helsinki, Finland. jaana.lindstrom{at}

  • Sources of funding: Academy of Finland; Julio Vainio Foundation; Ministry of Education; Novo Nordisk Foundation; Yrjö Jahnsson Foundation; Finnish Diabetes Research Foundation.

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