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Annual mammographic screening beginning at 40 years of age did not significantly reduce breast cancer mortality after 10 years in women

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 Q In women who are 40 years of age, does annual mammographic screening reduce breast cancer mortality after 10 years?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Gynaecology ★★★★★★☆ Oncology ★★★★★☆☆


Embedded ImageDesign:

randomised controlled trial (Age trial).

Embedded ImageAllocation:


Embedded ImageBlinding:


Embedded ImageFollow up period:

mean 10.7 years.

Embedded ImageSetting:

23 National Health Service breast screening units in England, Wales, and Scotland.

Embedded ImagePatients:

160 921 women 39–41 years of age (mean age 40 y).

Embedded ImageIntervention:

women who were allocated to the intervention group (n = 53 914) were offered annual screening by mammography up to and including the calendar year of their 48th birthday. Women who were allocated to the control group (n = 107 007) received usual medical care.

Embedded ImageOutcomes:

breast cancer mortality and all cause mortality. …

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  • * See glossary.

  • For correspondence: Dr S Moss, Institute of Cancer Research, Sutton, UK. sue.moss{at}

  • Sources of funding: Medical Research Council and Cancer Research and US National Cancer Research Institute