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Therapeutics
Review: SSRIs lead to improvement in depression by the end of the first week

https://doi.org/10.1136/ebm.12.3.72

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    Taylor MJ, Freemantle N, Geddes JR, et al. Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis. Arch Gen Psychiatry 2006;63:1217–23.
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 Q In patients with depression, do selective serotonin reuptake inhibitors (SSRIs) have an early or delayed onset of antidepressant action?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ GP/FP/Mental health ★★★★★★☆ Psychiatry ★★★★★☆☆

    METHODS

    Embedded ImageData sources:

    CENTRAL (Cochrane Central Register of Controlled Trials) and reference lists of randomised controlled trials (RCTs) and systematic reviews.

    Embedded ImageStudy selection and assessment:

    RCTs in any language were included if they reported outcome measures for SSRI treatment at ⩾2 time points. RCTs in older adults (⩾65 y) or in patients with specific comorbidities were excluded. 50 RCTs were identified, of which 28 (n = 5872) provided sufficient data for analysis. SSRIs used were …

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    Footnotes

    • For correspondence: Dr M J Taylor, University of Oxford, Oxford, UK. matthew.taylor{at}psych.ox.ac.uk

    • Sources of funding: Wellcome Trust Research Training Fellowship and National Alliance for Research on Schizophrenia and Depression.