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Review: diacerein is more effective than placebo and is as effective as NSAIDs for knee and hip osteoarthritis

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 Q In patients with knee or hip osteoarthritis, is diacerein more effective than placebo or other active treatments in reducing pain and improving function?

Clinical impact ratings Rheumatology ★★★★★★☆


Embedded ImageData sources:

PubMed, Medline, EMBASE/Excerpta Medica, Google, Yahoo, AltaVista, arthritis journals, personal files, reference lists, and the drug company.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs), published or reported in English, French, or German between 1985 and 2004, that compared diacerein with placebo or another active treatment in patients with knee or hip osteoarthritis. 19 RCTs (n = 3058, mean age range 48–67 y, 68% women) met the selection criteria, 16 of which were double blinded. Methodological quality of individual trials was assessed using the Jadad scale.

Embedded ImageOutcomes:

pain, function, and use of other medications for pain relief. Outcomes were assessed at 2 time points: at the end of active treatment (duration 1–36 mo, median 3 …

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  • For correspondence: Dr B F Leeb, Lower Austrian Centre for Rheumatology, Stockerau, Austria. leeb.humanis{at}

  • Source of funding: TRB Chemedica International SA.