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Etomidate had shorter induction and recovery times than midazolam for fracture reduction

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 Q In children and adolescents presenting with a displaced extremity fracture who require sedation, does etomidate show faster onset and recovery than midazolam?

Clinical impact ratings Emergency medicine ★★★★★★☆ Paediatrics (general) ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, investigators, {data collectors, outcome assessors, and data analysts}).*

Embedded ImageFollow up period:

up to discharge.

Embedded ImageSetting:

emergency department (ED) of a tertiary care paediatric hospital.

Embedded ImagePatients:

100 patients 2–18 years of age (mean age 8.7 y, 50% boys) who presented to the ED with a displaced extremity fracture requiring sedation and analgesia for closed reduction. Exclusion criteria included respiratory tract infection, haemodynamic instability, recent head injury, known seizure disorder, heart or lung disease, craniofacial anomaly, adrenocortical dysfunction, pregnancy, allergy to study drugs, consumption of solids <6 hours or liquids <2 hours previously, and inability to obtain …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr L Di Liddo, Centre Hospitalier Universitaire Ste-Justine, Montréal, Quebec, Canada. diliddolydia{at}

  • Source of funding: Fonds d’opération pour les projects de recherche de l’Hôpital Ste-Justine.