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Review: prokinetics, histamine H2 receptor antagonists, antimuscarinics, and proton pump inhibitors improve global symptoms in non-ulcer dyspepsia

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 Q In patients with non-ulcer dyspepsia (NUD), do antacids, histamine H2 receptor antagonists (H2RAs), proton pump inhibitors (PPIs), prokinetics (PROK), mucosal protecting agents (MPAs), and antimuscarinics improve symptoms?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Gastroenterology ★★★★★★★ Internal medicine ★★★★★★☆


Embedded ImageData sources:

Medline (1966 to January 2006), CINAHL (1982 to January 2006), EMBASE/Excerpta Medica (1988 to January 2006), Cochrane Central Register of Controlled Trials (Cochrane Library, Issue 4, 2005), SIGLE, bibliographies of relevant studies, experts in the field, and pharmaceutical companies.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) that compared antacids, H2RAs, PPIs, PROK, MPAs, or antimuscarinics with placebo or other drugs in patients with symptoms …

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  • For correspondence: Professor P Moayyedi, McMaster University, Hamilton, Ontario, Canada. moayyep{at}

  • Sources of funding: UK NHS Health Technology Assessment Programme; Medical Research Council; NHS Research and Development Programme.