Article Text

Download PDFPDF
Review: LABAs are better than leukotriene receptor antagonists when added to inhaled corticosteroids in recurrent asthma

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 Q In patients with recurrent asthma, what is the effectiveness of adding long acting β2 agonists (LABAs) or leukotriene receptor antagonists (LTRAs) to inhaled corticosteroids (ICSs)?

Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★★☆ Allergy & immunology ★★★★★★☆ Paediatrics ★★★★★☆☆


Embedded ImageData sources:

Medline, CINAHL, EMBASE/Excerpta Medica, Cochrane Central Register of Controlled Trials, Cochrane Airways Group Specialised Register (to March 2006), hand searches of respiratory journals and meeting abstracts, and bibliographies of relevant published and unpublished studies and reviews.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) that evaluated the effectiveness of adding LABAs (salmeterol or formoterol) or LTRAs (montelukast, pranlukast, zafirlukast, or zileuton) to ICSs for recurrent asthma. Rescue and asthma medications were permitted at a constant dose. 15 RCTs (age range …

View Full Text


  • For correspondence: Professor F Ducharme, The Montreal Children’s Hospital, Montreal, Quebec, Canada. francine.ducharme{at}

  • Sources of funding: Nederlands Asthma Fonds Netherlands and NHS Research and Development.