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Daily folic acid supplementation for 3 years improved cognitive function in older persons

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 Q In older persons, does daily folic acid supplementation for 3 years improve cognitive function?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Geriatrics ★★★★★★☆ GP/FP/Mental Health ★★★★★☆☆ Genetics ★★★★★☆☆ Neurology ★★★★★☆☆ Psychiatry ★★★★★☆☆


Embedded ImageDesign:

randomised placebo controlled trial (Folic Acid and Carotid Intima media Thickness [FACIT] trial).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {clinicians, participants, data collectors, outcome assessors, data safety and monitoring committee, manuscript writers, and data analysts/statisticians}.*

Embedded ImageFollow up period:

3 years.

Embedded ImageSetting:

Gelderland province, the Netherlands.

Embedded ImageParticipants:

818 men and postmenopausal women 50–70 years of age (mean age 60 y, 72% men) recruited from municipal and blood bank registries who reported ⩾80% compliance during a 6 week placebo run in period. 51 participants had 1 household member who was also enrolled and received …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr J Durga, Nestlé Research Centre, Lausanne, Switzerland. jane.durga{at}

  • Source of funding: Netherlands Organisation for Health Research and Development.