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After midtrimester amniocentesis the risk of spontaneous pregnancy loss was 6 per 10 000

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 Q What is the contemporary procedure-related risk of spontaneous pregnancy loss after midtrimester amniocentesis?

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prospective cohort study with follow up to birth (First and Second Trimester Evaluation of Risk [FASTER] trial).

Embedded ImageSetting:

15 centres in the US.

Embedded ImagePatients:

35 003 women, mean 30 years of age, who were enrolled in a study of prenatal screening for Down syndrome, {had a viable singleton pregnancy at the time for amniocentesis (16 wk gestation)}*, and had complete pregnancy outcome information available (95% of study participants). 3096 women (8.8%) underwent midtrimester amniocentesis (offered to those with a positive screening result or on request); 31 907 women who did not have amniocentesis formed the control group. Women who had amniocentesis were older (36 v 29 y) and more likely to have a history of miscarriage (34% v 26%) and a positive screening result in …

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  • * Information provided by author.

  • For correspondence: Dr K A Eddleman, Mount Sinai Medical Center, New York, NY, USA. keith.eddleman{at}

  • Sources of funding: National Institutes of Health.