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The ABCD, California, and unified ABCD2 risk scores predicted stroke within 2, 7, and 90 days after TIA

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 Q In patients with transient ischaemic attack (TIA), how does a new unified risk score (ABCD2) compare with the previously developed ABCD and California scores for predicting 2, 7, and 90 day stroke risk?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Neurology ★★★★★★☆ Internal medicine ★★★★★☆☆


Embedded ImageDesign:

6 cohort studies: 2 derivation cohorts (California emergency department [ED] and Oxford population) and 4 independent validation cohorts (California ED, California clinic, Oxford population, and Oxford clinic).

Embedded ImageSetting:

EDs and primary care clinics in the San Francisco Bay area, California, USA and family practices and specialist clinics in Oxfordshire, UK.

Embedded ImagePatients:

1916 patients (78% >60 y, 52% women) for derivation and 2893 patients (76% >60 y, 53% women) for validation who were diagnosed with TIA by the initial treating doctor.

Embedded ImageDescription of prediction guide:

The ABCD2 score was generated in the 2 original derivation cohorts by multivariate logistic regression analysis of individual risk factors from the ABCD and California scores. The risk score …

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