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↵* See glossary.
For correspondence: Dr W E Boden, Buffalo General Hospital, Buffalo, NY, USA.
Sources of funding: US Department of Veterans Affairs; Canadian Institutes of Health Research; Merck; Pfizer; Bristol-Myers Squibb; Fujisawa; Kos Pharmaceuticals; Datascope; Astra-Zeneca; Key Pharmaceutical; Sanofi-Aventis; First Horizon; GE Healthcare.