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Therapeutics
Review: lifestyle or pharmacological interventions prevent or delay type 2 diabetes in impaired glucose tolerance

https://doi.org/10.1136/ebm.12.4.108

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    Gillies CL, Abrams KR, Lambert PC, et al. Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis. BMJ 2007;334:299.
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 Q In persons with impaired glucose tolerance, do lifestyle or pharmacological interventions prevent or delay type 2 diabetes mellitus (DM)?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Endocrine ★★★★★★☆ Obesity—physician ★★★★★★☆

    METHODS

    Embedded ImageData sources:

    Medline (1966 to July 2006), EMBASE/Excerpta Medica (1980 to July 2006), Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews (Issue 2, 2006), references of relevant articles, and experts in the field.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) that evaluated an intervention to delay or prevent type 2 DM in persons with impaired glucose tolerance and had an outcome measurement of diabetes. 21 RCTs met the selection criteria, and 17 RCTs …

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    Footnotes

    • For correspondence: Dr C L Gillies, University of Leicester, Leicester, UK. clg13{at}le.ac.uk

    • Source of funding: UK Medical Research Council and Economic and Social Research Council.