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  • Review: drugs for mild to moderate hypertension in pregnancy reduce the risk of severe hypertension but not pre-eclampsia

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Therapeutics
Review: drugs for mild to moderate hypertension in pregnancy reduce the risk of severe hypertension but not pre-eclampsia

https://doi.org/10.1136/ebm.12.4.116

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    Abalos E, Duley L, Steyn D, et al. Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev 2007;(1):CD002252.
    OpenUrlPubMed

    
 
 Q In pregnant women with mild to moderate hypertension, what are the benefits and risks of antihypertensive (anti-HT) drugs? Is one type of anti-HT drug better than another?

    Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ GP/FP/Obstetrics ★★★★★★☆ Internal medicine ★★★★★★☆ Nephrology ★★★★★★☆ Obstetrics ★★★★★★☆

    METHODS

    Embedded ImageData sources:

    Cochrane Pregnancy and Childbirth Group’s Trials Register (March 2006); Cochrane Central Register of Controlled Trials (2005, issue 3); and Medline, LILACS, and EMBASE/Excerpta Medica (to November 2005).

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) that evaluated any anti-HT drug (compared with placebo or no anti-HT drug [control] or another type of anti-HT drug) for mild to moderate hypertension during pregnancy. Quasi-randomised studies and those involving treatment for <7 days were excluded. 46 RCTs met the selection criteria: 28 RCTs compared anti-HT drugs with control (n = 3200) and 19 RCTs compared 2 types of anti-HT drugs (n = 1282).

    Embedded ImageOutcomes:

    severe hypertension, pre-eclampsia, fetal or neonatal death, preterm …

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    Footnotes

    • For correspondence: Dr E Abalos, Centro Rosarino de Estudios Perinatales, Rosario, Santa Fe, Argentina. crep{at}crep.com.ar

    • Sources of funding: Medical Research Council UK and World Health Organization.