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Q In pregnant women with mild to moderate hypertension, what are the benefits and risks of antihypertensive (anti-HT) drugs? Is one type of anti-HT drug better than another?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ GP/FP/Obstetrics ★★★★★★☆ Internal medicine ★★★★★★☆ Nephrology ★★★★★★☆ Obstetrics ★★★★★★☆
METHODS
Data sources:
Cochrane Pregnancy and Childbirth Group’s Trials Register (March 2006); Cochrane Central Register of Controlled Trials (2005, issue 3); and Medline, LILACS, and EMBASE/Excerpta Medica (to November 2005).
Study selection and assessment:
randomised controlled trials (RCTs) that evaluated any anti-HT drug (compared with placebo or no anti-HT drug [control] or another type of anti-HT drug) for mild to moderate hypertension during pregnancy. Quasi-randomised studies and those involving treatment for <7 days were excluded. 46 RCTs met the selection criteria: 28 RCTs compared anti-HT drugs with control (n = 3200) and 19 RCTs compared 2 types of anti-HT drugs (n = 1282).
Outcomes:
severe hypertension, pre-eclampsia, fetal or neonatal death, preterm …
Footnotes
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For correspondence: Dr E Abalos, Centro Rosarino de Estudios Perinatales, Rosario, Santa Fe, Argentina. crep{at}crep.com.ar
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Sources of funding: Medical Research Council UK and World Health Organization.
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