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Reducing infant exposure to food and dust mite allergens reduced the incidence of asthma and allergy at age 8 years

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 Q In infants, does the reduction in exposure to food and house dust mite allergens during the first year of life prevent the development of asthma and allergy in later childhood?

Clinical impact ratings Allergy & immunology ★★★★★★☆ Paediatrics (general) ★★★★★★☆


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (outcome assessors {and data analysts}).*

Embedded ImageFollow up period:

8 years.

Embedded ImageSetting:

Isle of Wight, UK.

Embedded ImageParticipants:

120 of 136 infants who were at high risk (ie, had ⩾2 members in immediate family with allergic disease, such as asthma, atopic dermatitis, or allergic rhinitis, or either parent or sibling had allergic disease plus infant had cord serum IgE >0.5 kU/l).

Embedded ImageIntervention:

prophylaxis (n = 58) or usual care (n = 62). Prophylaxis consisted of an infant diet that …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr S H Arshad, St Mary’s Hospital, Newport, UK. sha{at}

  • Source of funding: NHS R&D (South and East Region).