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Q In infants, does the reduction in exposure to food and house dust mite allergens during the first year of life prevent the development of asthma and allergy in later childhood?
Clinical impact ratings Allergy & immunology ★★★★★★☆ Paediatrics (general) ★★★★★★☆
METHODS
Design:
randomised controlled trial.
Allocation:
{concealed*}†.
Blinding:
blinded (outcome assessors {and data analysts}†).*
Follow up period:
8 years.
Setting:
Isle of Wight, UK.
Participants:
120 of 136 infants who were at high risk (ie, had ⩾2 members in immediate family with allergic disease, such as asthma, atopic dermatitis, or allergic rhinitis, or either parent or sibling had allergic disease plus infant had cord serum IgE >0.5 kU/l).
Intervention:
prophylaxis (n = 58) or usual care (n = 62). Prophylaxis consisted of an infant diet that …