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Absolute risk of subsequent fracture was similar in women and men

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 Q What is the risk of subsequent fracture after initial low impact fracture in women and men?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Geriatrics ★★★★★☆☆


Embedded ImageDesign:

inception cohort followed for median 16 years in women and 15 years in men (Dubbo Osteoporosis Epidemiology Study).

Embedded ImageSetting:

community study in Dubbo, New South Wales, Australia.

Embedded ImagePatients:

1242 patients ⩾60 years of age (905 women [mean age 78 y] and 337 men [mean age 77 y] at time of incident fracture) who had an initial low impact fracture (caused by a fall from a standing height or less) between January 1989 and April 2005. Patients with skull, finger, and toe fractures or an underlying condition that could predispose to pathological fracture were excluded.

Embedded ImagePrognostic factors:

smoking, alcohol, and dietary calcium intake; comorbid conditions and medications; anthropomorphic measurements; bone mineral density of the lumbar spine and femoral neck; quadriceps strength; and body sway.

Embedded ImageOutcomes:

subsequent fracture.


Among 905 women with initial fracture, 253 had a subsequent fracture over …

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  • For correspondence: Dr J R Center, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.{at}

  • Sources of funding: National Health & Medical Research Council; Merck Sharp & Dohme; Eli Lilly; GE Lunar Corporation.