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The Atkins diet led to more weight loss than the Zone diet in overweight and obese premenopausal women at 12 months

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 Q In overweight or obese premenopausal women, how do the Atkins; Zone; Lifestyle, Exercise, Attitudes, Relationships, and Nutrition (LEARN); and Ornish diets compare for weight loss?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Obesity—surgeon ★★★★★★☆ Obesity—physician ★★★★★☆☆


Embedded ImageDesign:

randomised controlled trial (The Atkins, Traditional, Ornish, Zone [A TO Z] Weight Loss Study).

Embedded ImageAllocation:

unclear allocation concealment.*

Embedded ImageBlinding:

blinded {data collectors, data analysts, and data safety and monitoring committee}.*

Embedded ImageFollow up period:

12 months.

Embedded ImageSetting:


Embedded ImagePatients:

311 premenopausal women 25–50 years of age (mean age 41 y, 71% white) who were overweight or obese (body mass index [BMI] 27–40 kg/m2), had stable body weight in the past 2 months, and stable medications for ⩾3 months. Exclusion criteria included diabetes; hypertension; …

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  • * See glossary.

  • Information provided by author.

  • For correspondence: Dr C D Gardner, Stanford University Medical School, Stanford, California, USA. cgardner{at}

  • Sources of funding: National Institutes of Health; Community Foundation of Southeastern Michigan; Human Health Services.

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