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Therapeutics
Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children

https://doi.org/10.1136/ebm.12.5.144

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    Clark E, Plint AC, Correll R, et al. A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics 2007;119:460–7.
    OpenUrlAbstract/FREE Full Text

    
 
 Q In children with musculoskeletal pain, what is the relative efficacy of ibuprofen, acetaminophen, and codeine?

    Clinical impact ratings Paediatrics ★★★★★★★ Emergency medicine ★★★★★★☆ Paediatric emergency medicine ★★★★★☆☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    {concealed}*.†

    Embedded ImageBlinding:

    blinded (patients [children and parents], {healthcare providers}*, and data collectors).†

    Embedded ImageFollow up period:

    120 minutes.

    Embedded ImageSetting:

    the emergency department of an academic, tertiary care children’s hospital in Ottawa, Ontario, Canada.

    Embedded ImagePatients:

    336 children 6–17 years of age (mean age 12 y, 60% boys) presenting to the emergency department with pain from a musculoskeletal injury to extremities, neck, or back that occurred in the previous 48 hours. Exclusion criteria included contraindication to a study drug, receipt of 1 of the study drugs in …

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    Footnotes

    • ↵* Information provided by author.

    • ↵† See glossary.

    • For correspondence: Dr A Plint, Children’s Hospital of Eastern Ontario, Ottawa, Ontario, Canada. plint{at}cheo.on.ca

    • Source of funding: Children’s Hospital of Eastern Ontario Research Institute.

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2007; 12 160-160 Published Online First: 01 Oct 2007. doi: 10.1136/ebm.12.5.160