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  • 10 day sequential therapy was more effective than 10 day triple drug therapy for eradicating Helicobacter pylori infection

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Therapeutics
10 day sequential therapy was more effective than 10 day triple drug therapy for eradicating Helicobacter pylori infection

https://doi.org/10.1136/ebm.12.5.146

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    Vaira D, Zullo A, Vakil N, et al. Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a randomized trial. Ann Intern Med 2007;146:556–63.
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 Q In patients with dyspepsia or peptic ulcer disease, is 10 day sequential therapy more effective than 10 day triple drug therapy for eradicating Helicobacter pylori infection?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Gastroenterology ★★★★★★☆ IM/Ambulatory care ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    {concealed}*.†

    Embedded ImageBlinding:

    blinded (patients, investigators, {data collectors, outcome assessors, data analysts, and data safety and monitoring committee}*).†

    Embedded ImageFollow-up period:

    8 weeks.

    Embedded ImageSetting:

    2 hospitals in Bologna and Rome, Italy.

    Embedded ImagePatients:

    300 patients ⩾18 years of age (mean age 49 y, 64% women) with dyspepsia or peptic ulcers who had never received treatment for H Pylori infection. Exclusion criteria included use of proton pump inhibitors, H2 receptor antagonists, bismuth preparations, or antibiotics in the past 2 weeks; concomitant use of anticoagulants or ketoconazole and glucocorticoids; Zollinger Ellison syndrome; …

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    Footnotes

    • ↵* Information provided by author.

    • ↵† See glossary.

    • For correspondence: Dr D Vaira, S. Orsola Hospital, Bologna, Italy. E-mail vairadin{at}med.unibo.it

    • Source of funding: No external funding.

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2007; 12 160-160 Published Online First: 01 Oct 2007. doi: 10.1136/ebm.12.5.160