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  • Routine rotavirus vaccinations of infants cost US$138 per case averted and US$197 190 per life year saved from a societal perspective

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Economics
Routine rotavirus vaccinations of infants cost US$138 per case averted and US$197 190 per life year saved from a societal perspective

https://doi.org/10.1136/ebm.12.5.153

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    Widdowson MA, Meltzer MI, Zhang X, et al. Cost-effectiveness and potential impact of rotavirus vaccination in the United States. Pediatrics 2007;119:684–97.
    OpenUrlAbstract/FREE Full Text

    
 
 Q Are routine rotavirus vaccinations (3 times/infant) cost effective in the US?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Paediatrics (general) ★★★★★★☆ Public health ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    cost effectiveness study using a probabilistic (Monte Carlo) model.

    Embedded ImageSetting:

    nationwide in the US.

    Embedded ImagePatients:

    a hypothetical cohort of 4 010 000 children monitored from 0 to 59 months of age.

    Embedded ImageIntervention:

    routine vaccinations for infants at 2, 4, and 6 months of age with a pentavalent human bovine reassortant rotavirus vaccine (PVR) (RotaTeq; Merck, Whitehouse Station, NJ, USA) or no vaccinations.

    Embedded ImageOutcomes:

    deaths, hospital admissions, emergency department visits, office visits, and episodes with home care; and the cost effectiveness ratio per case (any disease) averted, per serious case (hospital admission, …

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    Footnotes

    • For correspondence: Dr M A Widdowson, Centers for Disease Control and Prevention, Atlanta, GA, USA. mwiddowson{at}cdc.gov

    • Source of funding: Centers for Disease Control and Prevention.