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Routine rotavirus vaccinations of infants cost US$138 per case averted and US$197 190 per life year saved from a societal perspective

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 Q Are routine rotavirus vaccinations (3 times/infant) cost effective in the US?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Paediatrics (general) ★★★★★★☆ Public health ★★★★★★☆


Embedded ImageDesign:

cost effectiveness study using a probabilistic (Monte Carlo) model.

Embedded ImageSetting:

nationwide in the US.

Embedded ImagePatients:

a hypothetical cohort of 4 010 000 children monitored from 0 to 59 months of age.

Embedded ImageIntervention:

routine vaccinations for infants at 2, 4, and 6 months of age with a pentavalent human bovine reassortant rotavirus vaccine (PVR) (RotaTeq; Merck, Whitehouse Station, NJ, USA) or no vaccinations.

Embedded ImageOutcomes:

deaths, hospital admissions, emergency department visits, office visits, and episodes with home care; and the cost effectiveness ratio per case (any disease) averted, per serious case (hospital admission, …

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  • For correspondence: Dr M A Widdowson, Centers for Disease Control and Prevention, Atlanta, GA, USA. mwiddowson{at}

  • Source of funding: Centers for Disease Control and Prevention.