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Review: vaccines against human papillomavirus prevent cervical cancer precursors in young women for at least 3 years

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Do vaccines against human papillomavirus (HPV) prevent HPV 16/18 related cervical intraepithelial neoplasia grade 2 or 3 (CIN 2/3) and adenocarcinoma in situ (AIS) in young women?

Ault KA, for the Future II Study Group. Effect of prophylactic human papillomavirus L1 virus-like-particle vaccine on risk of cervical intraepithelial neoplasia grade 2, grade 3, and adenocarcinoma in situ: a combined analysis of four randomised clinical trials. Lancet 2007;369:1861–8.

Clinical impact ratings GP/FP/Primary care ★★★★★★⋆ Gynaecology ★★★★★★⋆ Public health ★★★★★★⋆


Embedded ImageDesign:

prespecified combined analysis of 4 randomised controlled trials.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (clinicians, participants, outcome assessors, and adjudication committee).*

Embedded ImageFollow-up period:

mean 3 years (maximum 4 y). Follow-up started on day 1 in the intention-to-treat and susceptible populations and 1 month after the third dose of vaccine in the per protocol population.

Embedded ImageSetting:

clinics in North America, Latin America, …

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  • Source of funding: Merck Research Laboratories.