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Warfarin reduced major stroke more than aspirin in elderly patients with atrial fibrillation in primary care.

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In elderly patients with atrial fibrillation (AF) in primary care, is warfarin more effective than aspirin for preventing major stroke, arterial embolism, and intracranial haemorrhage?

Mant J, Hobbs FDR, Fletcher K, et al. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet 2007;370:493–503.

Clinical impact ratings GP/FP/Primary care ★★★★★★⋆ Geriatrics ★★★★★★⋆ Cardiology ★★★★★★⋆ Haematology ★★★★★★⋆ Neurology ★★★★★★⋆


Embedded ImageDesign:

randomised controlled trial (Birmingham Atrial Fibrillation Treatment of the Aged [BAFTA] study).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (outcome assessors).*

Embedded ImageFollow-up period:

mean 2.7 years.

Embedded ImageSetting:

234 general practices in England and Wales.

Embedded ImagePatients:

973 patients ⩾75 years of age (mean age 81y, 55% men) with AF or flutter within the past 2 years (confirmed by electrocardiography). Exclusion criteria included terminal illness, rheumatic heart disease, major …

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