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Prednisolone plus paracetamol (acetaminophen) was as effective as indomethacin plus paracetamol but had fewer adverse effects in acute gout-like arthritis

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In patients with acute gout-like arthritis, what is the analgesic efficacy of prednisolone plus paracetamol compared with indomethacin plus paracetamol?

Man CY, Cheung IT, Cameron PA, et al. Comparison of oral prednisolone/paracetamol and oral indomethacin/paracetamol combination therapy in the treatment of acute goutlike arthritis: a double-blind, randomized, controlled trial. Ann Emerg Med 2007;49:670–7.

Clinical impact ratings GP/FP/Primary care ★★★★★★⋆ IM/Ambulatory care ★★★★★★★ Emergency medicine ★★★★★★⋆ Rheumatology ★★★★★⋆⋆


Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients and {healthcare providers}*).†

Embedded ImageFollow-up period:

14 days.

Embedded ImageSetting:

an emergency department (ED) of a large teaching hospital in Hong Kong, China.

Embedded ImagePatients:

90 patients >17 years of age (mean age 65 y, 82% men) with acute gouty arthritis who presented to the ED within 3 days of pain onset and had ⩾1 …

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  • Source of funding: no external funding.