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Therapeutics
Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures
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http://dx.doi.org/10.1136/ebm.12.6.176

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    In children presenting to the emergency department (ED) with acute long-bone fractures, is intranasal fentanyl equivalent to intravenous (IV) morphine for pain control?

    Borland M, Jacobs I, King B, et al. A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department. Ann Emerg Med 2007;49:335–40.

    Clinical impact ratings Paediatric emergency medicine ★★★★★★★ Emergency medicine ★★★★★★⋆ Paediatrics ★★★★★★⋆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    {concealed}*.†

    Embedded ImageBlinding:

    blinded (patients, {clinicians, data collectors, outcome assessors, data analysts, and safety and monitoring committee}*).†

    Embedded ImageFollow-up period:

    30 minutes after initial analgesic administration.

    Embedded ImageSetting:

    tertiary pediatric ED in a hospital in Australia.

    Embedded ImagePatients:

    67 patients, 7–15 years of age (mean age 11 y, 79% with radius or ulna fractures), who presented to the ED with …

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    Footnotes

    • Source of funding: ACEM Morson Taylor Research Grant.

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    Copyright information:

    2007 by the BMJ Publishing Group for Evidence-Based Medicine and by the ACP for portions reproduced from ACP Journal Club