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Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy for non-erosive GORD

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In patients with gastro-oesophageal reflux disease (GORD), is on-demand maintenance therapy with proton pump inhibitors (PPIs) effective for controlling symptoms and preventing relapse?

Pace F, Tonini M, Pallotta S, et al. Systematic review: maintenance treatment of gastro-oesophageal reflux disease with proton pump inhibitors taken ‘on-demand.’ Aliment Pharmacol Ther 2007;26:195–204.

Clinical impact ratings GP/FP/Primary care ★★★★★★⋆ Internal medicine ★★★★★★⋆ Gastroenterology ★★★★★⋆⋆


Embedded ImageData sources:

Medline and Cochrane Controlled Trials Register (to December 2006), and reference lists.

Embedded ImageStudy selection and assessment:

studies published in English as full articles that compared on-demand maintenance therapy, using PPIs or H2-receptor antagonists, with placebo or continuous maintenance therapy in patients with GORD, with or without erosive oesophagitis. 17 articles reporting on 16 studies (n = 14 142) met the selection criteria. All studies used PPIs (esomeprazole, 20 or 40 mg; …

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