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An intensive lifestyle intervention reduced weight and cardiovascular disease risk factors in obese participants with type 2 diabetes at 1 year in an interim analysis

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In overweight or obese participants with type 2 diabetes, does an intensive lifestyle intervention (ILI) reduce weight and cardiovascular disease risk factors?

Pi-Sunyer X, Blackburn G, Brancati FL, et al. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care 2007;30:1374–83.

Clinical impact ratings GP/FP/Primary care ★★★★★★⋆ IM/Ambulatory care ★★★★★⋆⋆ Endocrine ★★★★★★⋆


Embedded ImageDesign:

randomised controlled trial (RCT) (Action for Health in Diabetes [Look AHEAD] trial).

Embedded ImageAllocation:


Embedded ImageBlinding:

{data collectors and outcome assessors}*.†

Embedded ImageFollow-up period:

1 year.

Embedded ImageSetting:

16 centres in the US.

Embedded ImageParticipants:

5145 participants 45–75 years of age (mean age 59 y, 60% women) with type 2 diabetes and body mass index >25 …

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  • Source of funding: National Institutes of Health.