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Review: increased waist circumference or waist-to-hip ratio is associated with increased risk of cardiovascular events

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What is the relation between waist circumference or waist-to-hip ratio (WHR) and cardiovascular disease (CVD)?

de Koning L, Merchant AT, Pogue J, et al. Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: metaregression analysis of prospective studies. Eur Heart J 2007;28:850–6.

Clinical impact ratings GP/FP/Primary care ★★★★★★⋆ IM/Ambulatory care ★★★★★★⋆


Embedded ImageData sources:

Medline (1966 to November 2006), EMBASE/Excerpta Medica (1980 to week 45, 2006), Cochrane Library (to 2006), bibliographies of relevant studies, and authors.

Embedded ImageStudy selection and assessment:

English-language prospective cohort studies or randomised controlled trials that reported relative risks (or the data to calculate them) for CVD. CVD was defined as fatal or non-fatal coronary heart disease (myocardial infarction, ischaemic heart disease, coronary …

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  • Sources of funding: Heart and Stroke Foundation of Canada and Canadian Institutes of Health Research.