Article Text

Download PDFPDF
Review: quadruple therapies appear to be more effective than triple therapies for single-drug–resistant H pylori

Statistics from

L Fischbach

Dr L Fischbach, University of North Texas Health Science Center, Fort Worth, TX, USA;



what is the effect of drug resistance on therapies for Helicobacter pylori infection? Which therapies are most effective for eradicating nitroimidazole (NTM)- or clarithromycin (CTM)-resistant H pylori?

Data sources:

Medline (to February 2007) and bibliographies of relevant reviews.

Study selection and assessment:

English- or Spanish-language studies evaluating triple or quadruple therapies for eradicating H pylori in patients who were either all sensitive or all resistant to CTM or NTM. Studies had to include ⩾4 patients per treatment group with H pylori infection at baseline. Studies of monotherapy or dual therapies were excluded. 93 randomised controlled trials (RCTs) (n = 10 178) met the selection criteria; 68% of treatment groups came from RCTs, 67% of patients …

View Full Text


  • Source of funding:no external funding.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.