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Review: TCAs, anticonvulsants, opioids, and capsaicin cream are effective for diabetic neuropathy

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M C Wong

Mr M C Wong, United Christian Hospital, Hong Kong, China;



in adults with diabetes, how effective are treatments for painful diabetic neuropathy?

Search methods:

Medline, EMBASE/Excerpta Medica, Evidence Based Medicine Reviews—ACP Journal Club, and Cochrane Central Register of Controlled Trials (to October 2006); and reference lists.

Study selection and assessment:

randomised, double-blind, placebo-controlled trials (RCTs) with sample size ⩾10, published in English as full articles, that evaluated the analgesic effects of oral or topical pain-relieving drugs (excluding Chinese herbal medicines) in adults with diabetic neuropathy. Quality assessment of individual trials was based on the 5-point Jadad score; trials with scores ⩽2 were excluded. 25 RCTs (n = 3290, range of mean ages 50–64 y) met the selection criteria; 17 …

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  • Source of funding: no external funding.