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Therapeutics
Review: TCAs, anticonvulsants, opioids, and capsaicin cream are effective for diabetic neuropathy

https://doi.org/10.1136/ebm.13.1.21

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    M C Wong

    Mr M C Wong, United Christian Hospital, Hong Kong, China; wongmc0829@yahoo.com.hk

    REVIEW PROCESS

    Aim:

    in adults with diabetes, how effective are treatments for painful diabetic neuropathy?

    Search methods:

    Medline, EMBASE/Excerpta Medica, Evidence Based Medicine Reviews—ACP Journal Club, and Cochrane Central Register of Controlled Trials (to October 2006); and reference lists.

    Study selection and assessment:

    randomised, double-blind, placebo-controlled trials (RCTs) with sample size ⩾10, published in English as full articles, that evaluated the analgesic effects of oral or topical pain-relieving drugs (excluding Chinese herbal medicines) in adults with diabetic neuropathy. Quality assessment of individual trials was based on the 5-point Jadad score; trials with scores ⩽2 were excluded. 25 RCTs (n = 3290, range of mean ages 50–64 y) met the selection criteria; 17 …

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    Footnotes

    • Source of funding: no external funding.