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Aetiology
N-terminal pro-B-type natriuretic peptide concentrations ⩾100 ng/l increased risk of all-cause mortality

https://doi.org/10.1136/ebm.13.1.26

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    W März

    Dr W März, Synlab Center of Laboratory Diagnostics, Heidelberg, Germany; maerz@synlab.de

    STUDY QUESTION

    In patients with or without stable coronary artery disease (CAD), what is the relation between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and risk of cardiovascular (CV) and all-cause mortality?

    STUDY DESIGN

    Design:

    prospective hospital-based cohort study (The Ludwigshafen Risk and Cardiovascular Health Study).

    Setting:

    Ludwigshafen General Hospital, Ludwigshafen, Germany.

    Patients:

    1641 patients (mean age 61 y, 69% men) who had coronary angiography but did not have major non-CV disease; 1135 patients had stable CAD and 506 did not have stable CAD. Exclusion criteria were unstable angina, ST-segment elevation myocardial infarction (STEMI), non-STEMI, or valve disease.

    Risk factors:

    NT-proBNP concentrations (100–399 ng/l, 400–1999 ng/l, and …

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    Footnotes

    • Source of funding: Roche Diagnostics.