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G A Bachmann
Dr G A Bachmann, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA; email@example.com
randomised, placebo-controlled trial.
blinded (patients, healthcare providers, and data collectors).*
48 centres in the USA.
425 healthy postmenopausal women ⩾40 years of age (mean age 53 y, mean time since menopause 9 y) who had an average of ⩾7 (mean 10) moderate or severe hot flushes per day for ⩾1 week during screening. Exclusion criteria included abnormal Pap test result, abnormal vaginal bleeding, and a history of thrombophlebitis or thromboembolic disorder.
transdermal patches delivering 0.023 mg/day 17β-oestradiol (E2) plus 0.0075 mg/day levonorgestrel (low-dose group, n = 145), 0.014 mg/day E2 (micro-dose group, n = 147), or no E2 (placebo group, n = 133).
frequency and severity of hot …
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