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Review: long-acting insulin analogues do not improve glycaemic control but reduce nocturnal hypoglycaemia

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Dr K Tran

Correspondence to: Dr K Tran, Canadian Agency for Drugs and Technologies in Health, Ottawa, Ontario, Canada;


In patients with diabetes mellitus, what is the efficacy of long acting insulin analogues (LAIAs) compared with human insulin or oral antidiabetic agents?


Studies selected compared LAIAs (insulin glargine or insulin detemir) with conventional human insulin (including neutral protamine Hagedorn [NPH]) or oral antidiabetic agents in patients with type 1 or 2, or gestational diabetes. Outcomes included glycaemic control (haemoglobin A1c [HbA1c] concentration) and hypoglycaemic episodes.


Medline, EMBASE/Excerpta Medica, BIOSIS Previews, PASCAL, PubMed, and Cochrane Database of Systematic Reviews (1990 to February 2006); Health Economics Evaluation Database; and websites of regulatory and health technology assessment agencies and professional associations were searched for randomised controlled …

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  • Source of funding: Canadian federal, provincial, and territorial governments.