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Dr K Gupta
Correspondence to: Dr K Gupta, Yale University, West Haven, CT, USA; email@example.com
randomised controlled equivalence trial.
a university-based outpatient clinic in the USA.
338 women 18–45 years of age (median age 21 y) who were in good general health and had symptoms of acute cystitis (dysuria, frequency, and/or urgency) and a urine culture with ⩾102 colony forming units/ml of a uropathogen. Exclusion criteria included pregnancy, lactation, lack of regular contraceptive use, diabetes mellitus, known anatomical abnormalities of the urinary tract, allergy to study drugs, use of an antimicrobial agent for <2 weeks, and use of prophylactic antibiotics.
nitrofurantoin, 100 mg twice daily for 5 days (n = 171), or trimethoprim-sulfamethoxazole (TMP-SMX), 1 double-strength tablet twice daily for 3 days (n = 167).
clinical cure at 30 days (percentage …
Source of funding: Procter & Gamble Inc and US Public Health Service.