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  • Review: misoprostol and intramuscular prostaglandins do not prevent postpartum haemorrhage more than injectable uterotonics

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Therapeutics
Review: misoprostol and intramuscular prostaglandins do not prevent postpartum haemorrhage more than injectable uterotonics

https://doi.org/10.1136/ebm.13.3.82

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    Dr A M Gülmezoglu

    Correspondence to: Dr A M Gülmezoglu, World Health Organization, Geneva, Switzerland; gulmezoglum@who.int

    QUESTION

    How effective are prophylactic prostaglandins in preventing postpartum haemorrhage (PPH)?

    REVIEW SCOPE

    Selected studies compared a prostaglandin with no uterotonic agent, placebo, or another uterotonic agent as part of the routine management of the third stage of labour. Outcomes were severe PPH (blood loss ⩾1000 ml), need for blood transfusion, use of additional uterotonics, and adverse effects.

    REVIEW METHODS

    Cochrane Pregnancy and Childbirth Group’s trials register (February 2007) and PubMed (July 2006) were searched for randomised controlled trials (RCTs). 46 RCTs (n = 42 621) were included; 32 used adequate allocation concealment.

    MAIN RESULTS

    The table shows results for oral misoprostol. Rectal misoprostol …

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    Footnotes

    • Source of funding: no external funding.