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Review: calcium supplementation during pregnancy reduces the risk of pre-eclampsia

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Dr G J Hofmeyr

Correspondence to: Dr G J Hofmeyr, University of the Witwatersrand, East London, South Africa;


Does calcium supplementation during pregnancy reduce the risk of high blood pressure, pre-eclampsia, and related maternal and neonatal adverse outcomes?


Selected studies compared calcium supplementation (⩾1 g/d) with placebo during pregnancy (starting at <35 wks’ gestation) for prevention of hypertensive disorders of pregnancy. Outcomes were high blood pressure; pre-eclampsia; maternal death or serious morbidity; haemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome; preterm birth; stillbirth or neonatal death; and admission to neonatal intensive care unit.


Cochrane Pregnancy and Childbirth Group trials register (March 2006) and Cochrane Central Register of Controlled Trials …

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  • Source of funding: not stated.