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Aetiology
Glomerular filtration rate <45 ml/min/1.73 m2 with microalbuminuria was associated with increased CV death

http://dx.doi.org/10.1136/ebm.13.3.89

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    Dr. S Hallan

    Correspondence to: Dr. S Hallan, NTNU St. Olav University Hospital, Norway; stein.hallan@ntnu.no

    STUDY QUESTION

    Does estimated glomerular filtration rate (EGFR) combined with urine albumin excretion predict cardiovascular (CV) death?

    STUDY DESIGN

    Design:

    cohort study (second Nord-Trøndelag Health Study [HUNT II]) with a median 8.3-year follow-up.

    Setting:

    Nord-Trøndelag County, Norway.

    Patients:

    9709 participants ⩾20 years of age (mean age 62 y, 55% women, 76% had hypertension or diabetes) who provided 3 urine samples. Analysis was stratified by age.

    Risk factors:

    EGFR (⩾75 ml/min/1.73 m2, 60–74 ml/min/1.73 m2, 45–59 ml/min/1.73 m2, or <45 ml/min/1.73 m2) and albuminuria (optimal urine albumin-creatinine ratio [ACR] [<5 mg/g in men; <7 mg/g in women], high-normal ACR [5–19 mg/g in men; 7–29 mg/g in women], or microalbuminuria [ACR 20–200 mg/g in men; 30–300 mg/g …

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    Footnotes

    • Source of funding: not stated.