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Dr C Barbui, University of Verona, Verona, Italy; email@example.com
In participants with major depression, what is the effectiveness and acceptability of paroxetine?
Included studies compared any flexible- or fixed-dose (⩾20 mg/d) regimen of any pharmaceutical form of paroxetine with placebo in participants ⩾18 years of age with major depression. Outcomes included treatment discontinuation, depression, <50% improvement in symptoms, adverse events, and suicidal tendencies.
Medline; EMBASE/Excerpta Medica; Cochrane Collaboration Depression, Anxiety, and Neurosis Controlled Trials Register; Cochrane Central Register of Controlled Trials; and Glaxo-SmithKline Clinical Trial Register (all to December 2006) were searched for published and unpublished randomised placebo controlled trials (RCTs). 29 published RCTs and 11 unpublished RCTs (n = 6391) were included in …
Source of funding: Japanese Ministry of Education, Science and Technology and Japanese Ministry of Health Labour and Welfare.