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Review: α-antagonists and calcium channel blockers both improve spontaneous expulsion of kidney stones

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A Singh

Dr A Singh, Highland General Hospital, Oakland, CA, USA;


Do α-antagonists and calcium channel blockers (CCBs) increase spontaneous passage of kidney stones in adults?


Selected studies compared medical expulsive therapy, using an α-antagonist or CCB, with standard therapy in patients >18 years of age who were clinically and radiographically diagnosed with acute ureteral colic and started treatment in an inpatient or outpatient setting, or on referral to a urologist.

Outcome was proportion of patients who passed kidney stones (stone expulsion rate).


Medline, EMBASE/Excerpta Medica, and Cochrane Controlled Trials Register (1980 to Jan 2007); urological journals (2000 to Jan 2007) and their associated websites; abstracts of major urological conferences (2000–7); and reference lists of relevant articles were searched for randomised …

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