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Diagnosis
A rapid antibody test had high specificity but low sensitivity for diagnosing coeliac disease

https://doi.org/10.1136/ebm.13.4.118

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    M Maki

    Dr M Maki, Tampere University Hospital and Medical School, Tampere, Finland; markku.maki@uta.fi

    STUDY QUESTION

    Is a rapid antibody test accurate for diagnosing coeliac disease in children?

    STUDY DESIGN

    Design:

    blinded comparison of a rapid IgA antibody test with combined IgA plus IgG antibody test and small bowel biopsy.

    Setting:

    Jász-Nagykun-Szolnok county, Hungary.

    Patients:

    2690 children, 6 years of age, who had a preschool physical examination.

    Description of tests:

    the rapid antibody test detected IgA antibodies to tissue transglutaminase in whole blood from a finger prick (evaluated after 5 min). The combined antibody test detected IgA and IgG antibodies to endomysium and IgA antibodies to tissue transglutaminase from capillary blood.

    Diagnostic standard:

    biopsy samples of the small intestine were taken during upper gastrointestinal endoscopy from …

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    Footnotes

    • Source of funding: Hungarian Scientific Research Fund; Hungarian Ministry of Health; Research Fund of Tampere University Hospital; EU Marie Curie.